The College's campus in Taytay is located at East Rodriguez Avenue, Siena Heights, Barangay San Isidro, Taytay, Rizal. The main and oldest, facility, the two-storey Saint Catherine Building
Saint Catherine Building , was gutted by fire in 2002 and subsequently rebuilt. A four story building was constructed which has a number of classrooms and has a large Speech Laboratory in the newly added third floor of the building. Houses for Freshman high school students also.

The Mother Natividad Pilapil O.P. Building
Mother Natividad Pilapil O.P. Building houses kindergarten 1 and 2, and grade one pupils, plus faculty rooms for their teachers. It is located through Gate 1 of the campus.

The Saint Dominic De Guzman Building, named for the founder of the Dominican order, houses the Sophomre, Junior and Senior high school students, Computer rooms for college and high school students and the Cyber program. It also houses the Registrar's office, guidance office, testing center, the high school library, the GLL office, the YLL office, and the Instructional media center.

The Saint Thomas Aquinas Building
Saint Thomas Aquinas Building contains instructional rooms for the college students, laboratories, and the college library. It can be accessed through Gates 3 and 4. The building is named for the 13th century philosopher.

The Our Lady of the Holy Rosary Building
Our Lady of the Holy Rosary Building houses the publishing office, the cafeteria
Rosary Building Canteen , the clinic
Rosary Building Clinic and the chapel
Rosary Building Chapel .

The Saint Jacques Centre de Formatione - Hotelliere et Restaurateur (Saint Jacques Center for International Hospitality Education - Hotel and Restaurant) houses the College's signature program in Hotel and Restaurant Management. Historically, the Parisian Dominican house was located in the parish of Saint Jacques.

The Mother Francisca Hall is an Auditorium. In addition, the San Lorenzo Ruiz Hall is named for the Filipino martyred during persecution of Japanese Christians under the 17th century Tokugawa Shogunate. The college Gymnasium offer student facilities, including the
St. Catherine Covered Court
St. Catherine Covered Court , an Olympic sized pool
Olympic sized pool , and the St. Martin Sports Complex
St. Martin Sports Complex .